Design of experiments assisted the development of inclusion complexes of ramipril using hydrophilic carriers for enhancement of solubility and dissolution rate

The goal of the present study was to develop inclusion complexes and polymers dispersions ramipril prepared by physical mixing, kneading, co-evaporation, solvent evaporation methods enhance drug solubility dissolution rate, thereby reduce dose side effects using selected hydrophilic carriers such as β-CD, PVP-K25, PEG 4000, HPMC K100M. formulations were characterized for in-vitro release studies. systematic optimization performed I-Optimal experimental design selecting factors type (X1), drug: carrier ratio (X2), method preparation (X3), response variables including percent yield (Y1), (Y2), Carr’s index (Y3) in 30 min (Y4). Mathematical modeling carried out a quadratic polynomial model. complex formulation (F27) an optimized batch numerical desirability function graphical with help space. co-evaporation showed maximum released pH 6.8 phosphate buffer compared pure other formulations. is feasible approach improve solubility, bioavailability, minimization drugs’ gastrointestinal toxicity upon oral administration ramipril.